Treatment with 6-gingerol-rich fraction of Zingiber officinale prevented the mercury chloride-induced morphological aberrations.
PMID:
Brain Res. 2024 Mar 1 ;1826:148741. Epub 2023 Dec 27. PMID: 38157955
Abstract Title:
Mercury chloride causes cognitive impairment, oxidative stress and neuroinflammation in male Wistar rats: The potential protective effect of 6-gingerol-rich fraction of Zingiber officinale
Abstract:
This study investigated the effects of 6-gingerol-rich fraction of Zingiber officinale (6-GIRIFZO) on mercury chloride (HgCl)-induced neurotoxicity in Wistar rats. Thirty -five male Wistar rats weighing between (150-200 g) were divided randomly into five groups (n = 7): group 1: control, received 0.5 mL of normal saline, group 2: received HgCl(5 mg/kg), group 3: received N-acetylcysteine (NAC) (50 mg/kg) as well as HgCl(5 mg/kg), group 4: received 6-GIRIFZO (100 mg/kg) and HgCl(5 mg/kg), group 5: had 6-GIRIFZO (200 mg/kg) and HgCl(5 mg/kg), consecutively for 14 days. On the day14, the rats were subjected to behavioural tests using a Morris water maze and novel object recognition tests. The rats were then euthanized to obtain brain samples for the determination of biochemical parameters (acetylcholinesterase (AchE), nitric oxide (NO), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), glutathione (GSH), tumor necrosis factor- alpha (TNF-α), nuclear factor kappa-B (NF-κB), interleukin-1β(IL-1β) and interleukin-6 (IL-6)) using standard methods. The result revealed a significant increase in escape latency and a significant decrease in recognition ratio in the rats that were exposed to HgClonly. However, 6-GIRIFZO produced a significant reduction in the escape latency and (p
