A synbiotic formulation of Lactobacillus reuteri and inulin alleviates ASD-like behaviors.
PMID:
Food Funct. 2024 Jan 2 ;15(1):387-400. Epub 2024 Jan 2. PMID: 38099485
Abstract Title:
A synbiotic formulation ofand inulin alleviates ASD-like behaviors in a mouse model: the mediating role of the gut-brain axis.
Abstract:
Autism Spectrum Disorder (ASD), a complex neurodevelopmental disorder marked by social communication deficits and repetitive behaviors, may see symptom amelioration through gut microbiota modulation. This study investigates the effects of a synbiotic – specifically a probiotic amplified by prebiotic supplementation – on ASD-like mouse model's social deficiencies. This model was establishedvalproic acid injection into pregnant females. Post-weaning, male progeny received daily synbiotic treatment, a combination of() and inulin, for four weeks. Results indicated that the synbiotic rectified social impairments and attenuated inflammatory cytokine expressions in the brain. Moreover, synbiotic intervention protected gut barrier integrity and altered the gut microbiota composition, enhancing the butyrate-producingabundance. The synbiotic elevated metabolites such as butyrate and 3-hydroxybutyric acid (3-HB), alongside upregulated genes associated with 3-HB synthesis in the colon and liver, and brain receptors. Conclusively, the synbiotic combination ofand inulin mitigated ASD-related social impairments, partiallytheir regulatory effect on the gut-brain axis.
