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Bacillus megaterium Renuspore® as a potential probiotic for gut health and detoxification of unwanted dietary contaminants.


Front Microbiol. 2023 ;14:1125616. Epub 2023 Apr 11. PMID: 37113219

Abstract Title: 

Renusporeas a potential probiotic for gut health and detoxification of unwanted dietary contaminants.


Exposure to diverse environmental pollutants and food contaminants is ever-increasing. The risks related to the bioaccumulation of such xenobiotics in the air and food chain have exerted negative effects on human health, such as inflammation, oxidative stress, DNA damage, gastrointestinal disorders, and chronic diseases. The use of probiotics is considered an economical and versatile tool for the detoxification of hazardous chemicals that are persistent in the environment and food chain, potentially for scavenging unwanted xenobiotics in the gut. In this study,MIT411 (Renuspore) was characterized for general probiotic properties including antimicrobial activity, dietary metabolism, and antioxidant activity, and for the capacity to detoxify several environmental contaminants that can be found in the food chain.studies revealed genes associated with carbohydrate, protein and lipid metabolism, xenobiotic chelation or degradation, and antioxidant properties.MIT411 (Renuspore) demonstrated high levels of total antioxidant activities, in addition to antimicrobial activity against, and. The metabolic analysis demonstrated strong enzymatic activity with a high release of amino acids and beneficial short-chain fatty acids (SCFAs). Moreover, Renusporeeffectively chelated the heavy metals, mercury and lead, without negatively impacting the beneficial minerals, iron, magnesium, or calcium, and degraded the environmental contaminants, nitrite, ammonia, and 4-Chloro-2-nitrophenol. These findings suggest that Renusporemay play a beneficial role in supporting gut health metabolism and eliminating unwanted dietary contaminants.

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